All-in-One Nanohybrids Combining Sonodynamic Photodynamic and Photothermal Therapies

Taydas D., Özler M. E., ERGÜL M., ŞAHİN İNAN Z. D., SÖZMEN F.

ACS Applied Materials and Interfaces, cilt.16, sa.33, ss.43387-43399, 2024 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 33
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1021/acsami.4c09715
  • Dergi Adı: ACS Applied Materials and Interfaces
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, EMBASE, INSPEC, MEDLINE
  • Sayfa Sayıları: ss.43387-43399
  • Anahtar Kelimeler: hollow nanohybrids, photodynamic therapy, photothermal therapy, sonodynamic therapy, thermosensitive polymer
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

A wide variety of methods are being developed to ultimately defeat cancer; while some of these strategies have shown highly positive results, there are serious obstacles to overcome to completely eradicate this disease. So, it is crucial to construct multifunctional nanostructures possessing intelligent capabilities that can be utilized to treat cancer. A possible strategy for producing these multifunctional nanostructures is to combine various cancer treatment techniques. Based on this point of view, we successfully synthesized multifunctional HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids. The peculiarities of these thermosensitive polymer-modified and protoporphyrin IX (PpIX)-loaded hollow nanohybrids are that they combine photodynamic therapy (PDT), sonodynamic therapy (SDT), and photothermal therapy (PTT) with an intelligent design. As an all-in-one nanohybrids, HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids were employed in the SDT-PDT-PTT combination therapy, which proved to have a synergistic therapeutic effect for in vitro tumor treatments against breast tumors.