Injectable In Situ Forming Microparticles: A Novel Drug Delivery System

Yapar E., İNAL Ö., Ozkan Y., Baykara T.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, cilt.11, sa.2, ss.307-318, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.4314/tjpr.v11i2.19
  • Dergi Adı: TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.307-318
  • Anahtar Kelimeler: Injectable, In situ forming, Microparticle system, Controlled drug delivery, CONTROLLED-RELEASE, LEUPROLIDE ACETATE, FORMULATION, IMPLANT, MICROSPHERES, MYOTOXICITY, EMULSIONS, DEVICES
  • Sivas Cumhuriyet Üniversitesi Adresli: Hayır

Özet

Pharmaceutical formulation research has recently been focusing on delivery systems which provide long therapeutic effects and reduced side effects, and involving simplified production stages and facilitated application process. In situ forming microparticle (ISM) systems, one of the latest approach in this field, offer a new encapsulation technique and meet the objectives stated above. Factors such as the carrier used to form the multiparticles, amount and type of drug and the vehicle type can be taken as the main performance criteria for these systems. Ongoing studies have shown that this new multiparticulate drug delivery system is suitable for achieving new implant delivery system with low risk of dose-dumping, capable of being modulated to exhibit varying release patterns, reproducible, easily applicable and well-tolerated compared with classically surgical implants.