Protective effects of melatonin and selenium against apoptosis of olfactory sensory neurons: A rat model study


Koc S., ÇAYLI S., Aksakal C., OCAKLI S., Soyalic H., SOMUK B. T. , ...Daha Fazla

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, cilt.30, 2016 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2500/ajra.2016.30.4313
  • Dergi Adı: AMERICAN JOURNAL OF RHINOLOGY & ALLERGY

Özet

Background: Selenium plays a role in the prevention of oxidative damage and has been linked to regulatory functions in cell growth, apoptosis, cell survival, and cytotoxicity. Melatonin has an antioxidant effect, which protects against a number of free radical species. Given its antioxidant properties, melatonin has been widely known to inhibit neuronal apoptosis. We examined the cytoprotective effects of melatonin and selenium in rat olfactory sensory neurons after rhinosinusitis by immunohistochemical evaluation of olfactory bulb mucosa.