Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats


Gursoy S., ÖZDEMİR E. , BAĞÇİVAN İ. , ALTUN A. , DURMUŞ N.

UPSALA JOURNAL OF MEDICAL SCIENCES, cilt.116, ss.238-246, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 116 Konu: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/03009734.2011.597889
  • Dergi Adı: UPSALA JOURNAL OF MEDICAL SCIENCES
  • Sayfa Sayıları: ss.238-246

Özet

Background. Alpha 2 (alpha(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (alpha(2)-adrenoceptor agonists) on morphine analgesia and tolerance in rats.