New solvated Mo(VI) complexes of isatin based asymmetric bisthiocarbohydrazones as potent bioactive agent: synthesis, DFT-molecular docking studies, biological activity evaluation and crystal structures Research Published: 06 September 2024

Akkaya B., Kaya Y., Erçağ A., Kaya S., Zorlu Y.

BIOMETALS, cilt.23, sa.1, ss.1-19, 2024 (SCI-Expanded)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s10534-024-00633-x
  • Dergi Adı: BIOMETALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1-19
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

New solvated Mo (VI) complexes were isolated from the reaction of [MoO 2 (acac) 2] with asymmetric isatin bisthiocarbohydrazone ligands. The ligands were obtained from the reaction of isatin monothiocarbohydrazone with 3, 5-dibromo salicylaldehyde (L1), 3, 5-dichloro salicylaldehyde (L2) and 3-chloro-5-bromo salicylaldehyde (L3), respectively. In the complexes, the ligands serve as ONS donors and coordinate to the [MoO 2] 2+ nucleus. The bonding sites are azomethine nitrogen atom, phenolic oxygen atom and thiol sulfur atom. The sixth coordination site is completed by an oxygen atom from an ethanol solvent. The ethanol-coordinated Mo (VI) complexes, C1–C3,[MoO 2 L (EtOH)](L: L1–L3), were characterized using elemental analysis, IR and 1 H NMR spectroscopies, and conductivity measurements. By crystallizing ethanol-solvated solid complexes from an EtOH/DMSO mixture, DMSO-solvated complexes …