Significant association between MDM2 T309G polymorphism and colorectal cancer

Atabey M., TAŞ A., Sari I., BOSTANCI M. E., TOPÇU Ö., SİLİĞ Y.

JOURNAL OF BUON, cilt.24, sa.3, ss.1137-1142, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2019
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1137-1142
  • Anahtar Kelimeler: colorectal cancer, polymorphism T309G (rs2279744), MDM2 gene, Turkish population, MDM2 PROMOTER POLYMORPHISM, P53, RISK, CARCINOMA, SNP309, SUSCEPTIBILITY, MDM2-SNP309, POPULATION, COLON, AGE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Purpose: The Murine double minute 2 (MDM2) gene plays a crucial role in regulating and suppressing the function of apoptotic pathway. We investigated the relationship between MDM2 gene SNP309 (T309G) (rs2279744) polymorphism and colorectal cancer (CRC) in a Turkish population.