Evaluation of the Effects of the Heart-Lung Machine on the Plasma Beta-2 Microglobulin Level

Polat V., Ada F.

Turk Fen Ve Saglik Dergisi, cilt.4, sa.1, ss.71-76, 2023 (ESCI)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.51972/tfsd.1239933
  • Dergi Adı: Turk Fen Ve Saglik Dergisi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Index Copernicus
  • Sayfa Sayıları: ss.71-76
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Purpose: In this study, it was aimed to investigate whether beta-2 microglobulin (β2M) blood plasma level is affected by cardiopulmonary bypass (CPB) and its effects on prognosis in surgeries performed using a heart-lung machine.

Material and Methods: The study was carried out on 33 patients who underwent cardiac surgery using a heart-lung machine in the cardiovascular surgery department of Sivas Cumhuriyet University. Plasma β2M levels were evaluated in peripheral venous blood samples taken just before the operation, thirty minutes after connecting to the heart-lung machine, and at the twenty-fourth postoperative hour.

Results: It was observed that a high β2M level was associated with long intensive care and hospital stay, prolonged intubation, increased inotrope requirement, and blood product use (P<.001). In addition; advanced age, tobacco use, hyperlipidemia, and hypertension were also associated with high β2M levels (P<.001). It was observed that the heart-lung machine did not affect the plasma β2M level (P=0.843).

Conclusion: The heart-lung machine did not affect the plasma β2M levels. However, it seems likely that high β2M levels can be used as a predictive marker for poor prognosis in open heart surgery.

Keywords: Beta-2 microglobulin, Cardiac surgery, Cardiopulmonary by-pass machine, Open heart surgery