ANTIDIABETIC PROPERTIES OF QUEBECOL AS NATURAL PHENOLIC COMPOUND: alpha -GLYCOSIDASE AND alpha -AMYLASE METABOLIC ENZYMES INHIBITION PROPERTIES


KOÇYİĞİT Ü. M.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.28, ss.1224-1228, 2019 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 28
  • Basım Tarihi: 2019
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Sayfa Sayıları: ss.1224-1228

Özet

This study aims to examine the inhibitory effect of Quebecol on alpha-glycosidase and alpha-amylase enzyme activities in comparison with acarbose as a standard. IC50 amounts were obtained by using the Quebecol-Induced Activity (%) - [Quebecol] graph and the Lineweaver-Burk graph. The IC50 values obtained with Quebecol were 28.56 nM for alpha-glycosidase and 211.82 nM for alpha-amylase, while the mean K-i value was 8.04 nM for alpha-glycosidase. The results of our study are expected to contribute to pharmaceutical research and pharmacological applications by providing insight into the biological effects of Quebecol.