The effects of Niguldipine pretreatment on cerebral vasospasm after subarachnoid haemorrhage in rabbits

Gurelik M., Bolat M., Ozturk M., Polat S., Goksel H.

NEUROSCIENCE RESEARCH COMMUNICATIONS, cilt.34, sa.1, ss.47-55, 2004 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Konu: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1002/nrc.10105
  • Sayfa Sayıları: ss.47-55


Several different mechanisms contribute to the pathogenesis of cerebral vasospasm after subarachnoid haemorrhage. Whatever these mechanisms are, the vessel contraction is ultimately induced by an increase of free intracellular Ca2+ in the arterial wall. In this study, we investigated the effect on cerebral blood flow of a new dihydropyridine derivative Ca-channel blocker Niguldipine, in an rabbit experimental cerebral vasospasm model. The cerebral blood flow was significantly decreased in the saline treatment group when compared with control group. Niguldipine pretreatment caused a significant increase in cerebral blood flow. This effect should be investigated further.