Tumors That Metastasize to the Respiratory System
Approaches to Metastatic Tumors in Pathology, NOVA Publications , ss.155-164, 2026
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2026
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.155-164
- Anahtar Kelimeler: lung, metastasis, tumor
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
The lungs are frequent targets of metastasis due to their central role in circulation. This section examines the metastatic process and highlights elements that aid identification of the primary site. Primary tumor type and microenvironment are important determinants of lung metastasis. The metastatic cascade comprises tumor progression to an aggressive phenotype, neovascularization, tissue invasion, intravascular spread, survival in transit, interaction with distant organs, extravasation, homing, micrometastatic formation, stromal invasion, and eventual colonization. Clinical and radiological features together with tumor characteristics may assist the differential diagnosis. However, additional immunohistochemical markers are often required to establish a definitive diagnosis. In most cases, except for mucinous adenocarcinomas, the primary site can be identified.