Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses

YILMAZ İ., Maras Z., Ozgur M. E., Durmaz M., ULUSOY H. İ., ERDOĞAN S., ...Daha Fazla

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, cilt.44, sa.6, ss.927-936, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 6
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1111/jvp.13003
  • Dergi Adı: JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.927-936
  • Anahtar Kelimeler: Arabian horses, HPLC, Metamizole, pharmacokinetics, solid-phase extraction, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, LIQUID-CHROMATOGRAPHY, DIPYRONE METABOLITES, MASS-SPECTROMETRY, BOVINE MUSCLE, RESIDUES, PLASMA, URINE, ACID, IONIZATION
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Metamizole sodium (MT) is an analgesic and antipyretic drug molecule used in humans, horses, cattle, swine, and dogs. Metamizole rapidly hydrolyzes and turns into methylamino antipyrine (MAA), an active primary metabolite of MT. The present study aims to determine the pharmacokinetic (PK) profiles of MT metabolites after intravenous (IV) and intramuscular (IM) administration into sex of Arabian horses (Equus ferus caballus) using a cross-over study design. The plasma samples were extracted by solid-phase extraction (SPE) method, and plasma concentrations of MT metabolites were analyzed by high-performance liquid chromatography (HPLC). After administrations of MT, plasma concentrations of methylamino antipyrine (MAA), amino antipyrone (AA), and acetylamino antipyrone (AAA) were determined within range of 15 min-12 h. Plasma concentrations of AA and AAA were lower than the plasma concentrations of major metabolite MAA at each sampling point. The PK parameters were statistically evaluated for MT's metabolites between male and female horses and also between IM and IV administrations of PK parameters such as C-max, t(max), t(1/2 lambda z), AUC(0-t), AUC(0-infinity), lambda z, Cl and V-ss (p < .05). The AUC(IM)/AUC(IV) ratio in female and male horses for MAA was 1.19 and 1.13, respectively. The AUC(IM)/AUC(IV) ratio for AA was lower than those found for MAA. AUC(IM)/AUC(IV) ratio was statistically significantly different between male and female horses for AA (p < .05). According to these results, some PK parameters such as Cmax, AUC, and MRT, MAA and AA concentrations have shown statistically significant differences by MT administrations.