Relationships between hypoxia induced factor-1 alpha and F-18-FDG PET/CT parameters in colorectal cancer

HASBEK, ZEKİYE; ÖZER, HATİCE; ERTÜRK, SEYİT; ERDİŞ, EDA; YÜCEL, BİRSEN; Ciftci, E.; Cakmakcilar, ALİ

doi:10.1016/j.remn.2019.05.006

Relationships between hypoxia induced factor-1 alpha and F-18-FDG PET/CT parameters in colorectal cancer

HASBEK Z., ÖZER H., ERTÜRK S. A., ERDİŞ E., YÜCEL B., Ciftci E., ...Daha Fazla

REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR, cilt.38, sa.6, ss.355-361, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 38 Sayı: 6
Basım Tarihi: 2019
Doi Numarası: 10.1016/j.remn.2019.05.006
Dergi Adı: REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.355-361
Anahtar Kelimeler: Hypoxia-inducible factor 1-alpha, Colorectal cancer, F-18-FDG PET/CT, Hypoxia, TUMOR, HIF-1-ALPHA, EXPRESSION, VOLUME, HIF-1
Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Aim: The hypoxia-inducible factor 1 (HIF-1) has a critical role in oxygen homeostasis and it is a transcriptional activator of angiogenesis, erythropoiesis, iron and glucose metabolism. Glucose metabolism rate is increased in some tumours via HIF-1 alpha. Our aim is to evaluate the relationship between hypoxia in colorectal cancer, PET parameters, necrotic tissue size and pathologic prognostic factors via using HIF-1 alpha.