Relationships between hypoxia induced factor-1 alpha and F-18-FDG PET/CT parameters in colorectal cancer


HASBEK Z. , ÖZER H. , ERTÜRK S. A. , ERDİŞ E. , YÜCEL B. , Ciftci E., ...Daha Fazla

REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR, cilt.38, ss.355-361, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 38 Konu: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.remn.2019.05.006
  • Dergi Adı: REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR
  • Sayfa Sayıları: ss.355-361

Özet

Aim: The hypoxia-inducible factor 1 (HIF-1) has a critical role in oxygen homeostasis and it is a transcriptional activator of angiogenesis, erythropoiesis, iron and glucose metabolism. Glucose metabolism rate is increased in some tumours via HIF-1 alpha. Our aim is to evaluate the relationship between hypoxia in colorectal cancer, PET parameters, necrotic tissue size and pathologic prognostic factors via using HIF-1 alpha.