Low-density lipoprotein and blood pressure are important risk factors for vasculopathy in children on dialysis: A single center study

Conkar Tunçay S., Keskinoğlu A., Bulut İ. K., Levent E., Hakverdi G., Kabasakal C.

Therapeutic Apheresis and Dialysis, cilt.26, sa.6, ss.1220-1225, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1111/1744-9987.13846
  • Dergi Adı: Therapeutic Apheresis and Dialysis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.1220-1225
  • Anahtar Kelimeler: cardiovascular disease, carotid intima-media thickness, dialysis, low-density lipoprotein, pediatric, pulse wave velocity, vasculopathy
  • Sivas Cumhuriyet Üniversitesi Adresli: Hayır

Özet

Introduction: We searched for risk factors of cardiovascular assessment among children on dialysis. Methods: This is a cross-sectional study of cardiovascular assessment of all patients on dialysis at Ege University Children's Hospital. Pediatric patients between the ages of 6 and 21 who were on HD and peritoneal dialysis treatment were included in the study. Cardiovascular evaluation included left ventricular mass index (LVMI), pulse wave velocity (PWV), and carotid intima-media thickness (cIMT) measurements. Results: Nineteen patients were included in this study. The LDL had a correlation with the cIMT z-score, but not to PWVz-score. Binary Logistic regression analysis found that only LDL was significantly associated to increased cIMT. Conclusion: This study reports an association between high LDL and high BP increased cIMT on dialyzed children. Strategies to reduce LDL and BP in dialysis patients may prevent vasculopathy and long-term cardiovascular complications.