Recent advances in modified poly (lactic acid) as tissue engineering materials

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Castañeda-Rodríguez S., González-Torres M., Ribas-Aparicio R. M., Del Prado‑Audelo M. L., Leyva‑Gómez G., Sönmez Gürer E., ...Daha Fazla

Journal of Biological Engineering, cilt.17, sa.1, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 17 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1186/s13036-023-00338-8
  • Dergi Adı: Journal of Biological Engineering
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, EMBASE, INSPEC, Directory of Open Access Journals
  • Anahtar Kelimeler: Biocomposite, Biotechnology, Fabrication, Nanotechnology, Poly (lactic acid), Tissue Engineering
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs or tissues and enhancing the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues. Renewable resources have been used to develop new materials, resulting in attempts to produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known to be biodegradable and it is produced from the fermentation of carbohydrates. PLA can be combined with other polymers to produce new biomaterials with suitable physicochemical properties for tissue engineering applications. Here, the advances in modified PLA as tissue engineering materials are discussed in light of its drawbacks, such as biological inertness, low cell adhesion, and low degradation rate, and the efforts conducted to address these challenges toward the design of new enhanced alternative biomaterials.