Necroptosis mediated by receptor interacting protein kinase 3 as critical players in experimental congenital hypothyroidism related neuronal damage

DUMAN G., ALÇIĞIR M. E., YAVUZ H.

NORTHERN CLINICS OF ISTANBUL, cilt.8, sa.5, ss.472-478, 2021 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.14744/nci.2021.26043
  • Dergi Adı: NORTHERN CLINICS OF ISTANBUL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.472-478
  • Anahtar Kelimeler: Congenital hypothyroidism, rat, receptor-acting protein kinase 3 activity, 3.6-Dibromo-alpha-([phenylamino] methyl)-9H-carbazole-9-ethanol, THYROID-HORMONE DISRUPTION, OXIDATIVE STRESS, ACTIVATION, DEATH
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Congenital hypothyroidism (CH) is literally described as congenital thyroid hormone imperfection. The primary objective of this research was to reveal the possible relation between receptor-acting protein kinase 3 (RIPK3) activity and neuronal damages in rat pups with CH. In addition, we evaluated the favorable impacts of 3.6-dibromo-alpha-([phenylamino] methyl)-9H-carbazole-9-ethanol (P7C3) reducing RIPK3 activity.