The Effects of Some Bis-1, 2, 4-Triazole Containing Aminomethyl Derivatives on MDA Levels and Vitamins in Tissues of Rats

Alayunt N. O., Karatepe M., Parlak A. E., Ulas M., Turkoglu S., Dastan S., ...Daha Fazla

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, cilt.41, sa.4, ss.707-713, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 4
  • Basım Tarihi: 2019
  • Dergi Adı: JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.707-713
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

It was reported that the 1, 2, 4-triazole and the derivatives of this compound demonstrate numerous activities in a pharmacological point of view. 1, 2, 4-Triazole moieties were employed in an extensive range of drug candidates, which are therapeutically promising and include anti-inflammatories, anti-anxiety compounds, sedatives, CNS stimulants, antimicrobial agents, and antimycotic ones such as intraconazole, fluconazole and voriconazole. In the current investigation, several aminomethyl derivatives, which contain bis-1, 2, 4-triazole, were newly synthesized and their impacts on the levels of antioxidant vitamins (A, C and E) and malondialdehyde (MDA) were examined in serum, kidney and liver of rats.