Could Zingiber officinale plant be effective against Omicron BA.2.75 of SARS-CoV-2?

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SARAÇ H., DEMİRBAŞ A., TÜZÜN B.

Turkish Computational and Theoretical Chemistry, cilt.7, sa.3, ss.42-56, 2023 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.33435/tcandtc.1198612
  • Dergi Adı: Turkish Computational and Theoretical Chemistry
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.42-56
  • Anahtar Kelimeler: ADME/T, Molecular docking, Omicron, SARS-CoV-2, Zingiber officinale
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Zingiber officinale plant was examined in this study. The chemicals found in this plant were identified using the GC-MS method. The activities of the determined chemical molecules against the SARS-CoV-2 Omicron variant were compared. We focused to determine whether Zingiber officinale plant would be an inhibitor against Omicron of SARS-CoV-2 in silico. As a result of theoretical calculations, Zingiber officinale plant was found to contain many chemicals as a result of GC-MS analysis. These chemicals were detected one by one and their activity values were calculated for the SARS-CoV-2 virus. As a result, molecules with high activity were detected. ADME/T properties were investigated in order to examine the drug properties of molecules with high activity. According to ADME/T results, these five molecules examined are suitable for use in human metabolism as drug molecules.