Could Zingiber officinale plant be effective against Omicron BA.2.75 of SARS-CoV-2?
Turkish Computational and Theoretical Chemistry, cilt.7, sa.3, ss.42-56, 2023 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.33435/tcandtc.1198612
- Dergi Adı: Turkish Computational and Theoretical Chemistry
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.42-56
- Anahtar Kelimeler: ADME/T, Molecular docking, Omicron, SARS-CoV-2, Zingiber officinale
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
Zingiber officinale plant was examined in this study. The chemicals found in this plant were identified using the GC-MS method. The activities of the determined chemical molecules against the SARS-CoV-2 Omicron variant were compared. We focused to determine whether Zingiber officinale plant would be an inhibitor against Omicron of SARS-CoV-2 in silico. As a result of theoretical calculations, Zingiber officinale plant was found to contain many chemicals as a result of GC-MS analysis. These chemicals were detected one by one and their activity values were calculated for the SARS-CoV-2 virus. As a result, molecules with high activity were detected. ADME/T properties were investigated in order to examine the drug properties of molecules with high activity. According to ADME/T results, these five molecules examined are suitable for use in human metabolism as drug molecules.