Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors

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ÖZER H., Yenicesu G., ARICI S., ÇETİN M., TUNCER E., ÇETİN A.

DIAGNOSTIC PATHOLOGY, cilt.7, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1186/1746-1596-7-124
  • Dergi Adı: DIAGNOSTIC PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Ovarian tumors, Immunohistochemistry, p53, p21, bax, bcl-2, Telomerase, c-kit, Metallothionein, REVERSE-TRANSCRIPTASE HTERT, PROGNOSTIC-SIGNIFICANCE, LOW-GRADE, MUTATIONAL ANALYSIS, CANCER CELLS, EXPRESSION, CARCINOMA, OVEREXPRESSION, GENE
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background: In many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle. This study was designed to evaluate immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, and bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in typing of benign, borderline, and malignant serous and mucinous ovarian tumors.