Designing BODIPY-based probes for fluorescence imaging of beta-amyloid plaques


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Sozmen F. , Kolemen S., Kumada H., Ono M., Saji H., Akkaya E. U.

RSC ADVANCES, vol.4, no.92, pp.51032-51037, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 92
  • Publication Date: 2014
  • Doi Number: 10.1039/c4ra07754g
  • Title of Journal : RSC ADVANCES
  • Page Numbers: pp.51032-51037

Abstract

Styryl-congutated BODIPY dyes which are structurally similar to known A beta peptide binding dyes, were designed and synthesized. The binding is accompanied by a large increase in the emission intensity in all cases, suggesting a high potential for use in the fluorescence imaging of A beta plaques.