Designing BODIPY-based probes for fluorescence imaging of beta-amyloid plaques

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Sozmen F., Kolemen S., Kumada H., Ono M., Saji H., Akkaya E. U.

RSC ADVANCES, cilt.4, sa.92, ss.51032-51037, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 92
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1039/c4ra07754g
  • Dergi Adı: RSC ADVANCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.51032-51037
  • Sivas Cumhuriyet Üniversitesi Adresli: Hayır

Özet

Styryl-congutated BODIPY dyes which are structurally similar to known A beta peptide binding dyes, were designed and synthesized. The binding is accompanied by a large increase in the emission intensity in all cases, suggesting a high potential for use in the fluorescence imaging of A beta plaques.