Akademik Veri Yönetim Sistemi
Autoimmunity and Cancer, Şahin Soner,Demir Kenan, Editör, NOVA Science Publishers Inc. , New York, ss.57-72, 2022
The majority of people consider cancer to be a single disease, but it is
actually a collection of more than 1000 distinct abnormalities in cell and
tissue function. However, all cancers have one trait in common: they are
all diseases characterized by unregulated cell division. Under normal
circumstances, the body regulates the generation of new cells quite
precisely. Specific DNA abnormalities in cancer cells cause disruptions
in cell communication and growth regulation that are typical in healthy
cells. Cancer cells that have evaded these restrictions can become
invasive and move to other regions of the body. At the molecular level,
cancer is primarily a hereditary disease. It is crucial to understand the
fundamental genetic alterations that occur at the somatic level when
cancer progresses. The genetics of cancer at the germline layer is still one
of the most intriguing and fascinating areas of cancer research, and it is
becoming even more so as DNA sequencing technology improves. This
has allowed researchers to identify the genetic underpinnings of
previously unknown inherited diseases. Newer technologies have also made it economically feasible to test patients for the presence of common
and hereditary cancer susceptibilities. As a result, cancer genetics has
become a significant part of the volume of work in clinical genetics
programs. This chapter focuses on cancer and autoimmune-related
genetic and genomic components.