Investigation of Tumor Suppressor miR-383 Expression in HPV-related Malignancies
Cumhuriyet Science Journal, cilt.47, sa.2, ss.251-257, 2026 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.17776/csj.1882570
- Dergi Adı: Cumhuriyet Science Journal
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.251-257
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
Although genetic changes were investigated in disease development previously, we now know that epigenetic changes also play a critical role in diseases. In addition to DNA methylation and histone modification, changes in non-coding RNA expression also contribute to pathological processes as epigenetic modulators. miRNAs are conserved molecules that bind complementarily to their encoded target mRNAs, thereby performing post- transcriptional regulation. MicroRNA-383 (miR-383) functions as a tumor suppressor in various cancers, but its expression pattern in HPV-associated cervical lesions remains unclear. This exploratory study aimed to investigate whether miR-383 expression is altered in HPV positive cervical tissues and to generate hypotheses for future mechanistic studies. In this study, miR-383 expression levels were analyzed using qRT-PCR in paired HPV-positive cervical tissue and adjacent normal tissue samples from 30 patients. Our preliminary findings suggest a potential trend toward miR-383 upregulation, warranting further validation in larger cohorts. The observed upregulation may reflect a compensatory host response against viral oncogenesis, potentially through miR-383 mediated repression of oncogenic targets such as SFN and PD L1, suggesting its role in restraining early cervical carcinogenesis and highlighting its potential as a biomarker in HPV related disease progression.