Association of MCP-1 promotor polymorphism with disease severity of Crimean-Congo hemorrhagic fever

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Bagci B., Bagci G., Buyuktuna S. A., Elaldi N.

JOURNAL OF MEDICAL VIROLOGY, cilt.92, sa.12, ss.2976-2982, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 92 Sayı: 12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/jmv.25790
  • Dergi Adı: JOURNAL OF MEDICAL VIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.2976-2982
  • Anahtar Kelimeler: Crimean-Congo hemorrhagic fever, disease severity, gene polymorphism, MCP-1, monocyte chemoattractant protein, MONOCYTE CHEMOATTRACTANT PROTEIN-1, NECROSIS-FACTOR-ALPHA, GENE POLYMORPHISMS, SERUM-LEVELS, INFECTION, THROMBOCYTOPENIA, ENDOTHELIUM, EXPRESSION, CHEMOKINES, PROGNOSIS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Crimean-Congo hemorrhagic fever (CCHF) is a thick-borne viral zoonotic disease. The pathogenesis and the reasons why cases have a mild or severe course in CCHF have not yet been explained. In this study, we investigated the relationship between promoter -2518 A/G single-nucleotide polymorphism (SNP) of the MCP-1 gene and the clinical course of CCHF. The MCP-1-2518 A/G SNP (rs1024611) frequency was examined in 128 virologically/serologically confirmed CCHF patients and 181 healthy controls by using the PCR-RFLP method. When CCHF patients and controls were compared, no significant difference was found between genotype distributions and allele frequencies of the -2518 A/G SNP of MCP-1 gene (P > .05). Compared to the AA genotype, both AG (P = .016; OR = 2.57) and GG genotype (P = .039; OR = 3.43) were found with significantly higher frequencies in mild/moderate cases than in severe cases. Compared to the AG + GG genotype, AA showed a significant risk for severe CCHF (60.0% vs 38.4%, P = .02; OR = 2.41). In contrast, the AG genotype showed a significant protective effect against severe disease compared to AA + GG genotype (29.1% vs 47.9%, P = .013; OR = 2.58). Compared to mild/moderate cases, the A allele was found to be significantly higher in severe cases (0.745 vs 0.623, P = .039; OR = 1.77). However, no significant relationship was found between fatal and nonfatal cases in terms of genotype or allele frequencies (P > .05). In conclusion, both -2518 AA genotype and A allele of MCP-1 were associated with disease severity, and the AG genotype had a protective effect against a severe disease course in CCHF patients.