Association of MCP-1 promotor polymorphism with disease severity of Crimean-Congo hemorrhagic fever.


Bagci B., Bagci G., Buyuktuna S. A. , Elaldi N.

Journal of medical virology, 2020 (SCI İndekslerine Giren Dergi)

  • Cilt numarası:
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/jmv.25790
  • Dergi Adı: Journal of medical virology

Özet

Abstract

Crimean‐Congo hemorrhagic fever (CCHF) is a thick‐borne viral zoonotic disease.

The pathogenesis and the reasons why cases have a mild or severe course in CCHF

have not yet been explained. In this study, we investigated the relationship between

promoter ‐2518 A/G single‐nucleotide polymorphism (SNP) of the MCP‐1 gene and

the clinical course of CCHF. The MCP‐1‐2518 A/G SNP (rs1024611) frequency

was examined in 128 virologically/serologically confirmed CCHF patients and

181 healthy controls by using the PCR‐RFLP method. When CCHF patients

and controls were compared, no significant difference was found between genotype

distributions and allele frequencies of the ‐2518 A/G SNP of MCP‐1 gene (P > .05).

Compared to the AA genotype, both AG (P = .016; OR = 2.57) and GG genotype

(P = .039; OR = 3.43) were found with significantly higher frequencies in mild/moderate

cases than in severe cases. Compared to the AG + GG genotype, AA showed a

significant risk for severe CCHF (60.0% vs 38.4%, P = .02; OR = 2.41). In contrast, the

AG genotype showed a significant protective effect against severe disease compared

to AA + GG genotype (29.1% vs 47.9%, P = .013; OR = 2.58). Compared to mild/

moderate cases, the A allele was found to be significantly higher in severe cases

(0.745 vs 0.623, P = .039; OR = 1.77). However, no significant relationship was found

between fatal and nonfatal cases in terms of genotype or allele frequencies (P > .05).

In conclusion, both ‐2518 AA genotype and A allele of MCP‐1 were associated

with disease severity, and the AG genotype had a protective effect against a severe

disease course in CCHF patients.