Chemistry Research Journal, cilt.3, ss.73-80, 2018 (Diğer Kurumların Hakemli Dergileri)
Background: The aim of the present study is to determine the correlation between the oxidative stress
marker and the antioxidant parameters with the aortic cross clamp and pump times and to make contribution to the
Methods: Fifty four elective patients for whom cardiopulmonary bypass operation was planned with different
indications were included in this study. While sixteen of fifty four patients were female, thirty eight patients were
male. MDA, GPx, GSH, CAT, and SOD were investigated in the blood samples.
Results: When the change in oxidative damage and antioxidant parameters in preoperative, operative, and
postoperative periods was examined in the present study; a statistically significant increase was observed in GSH
level and CAT enzyme activity in operative and postoperative periods compared to preoperative period. In the
present study, it was observed that there was no statistical difference in preoperative, operative, and postoperative
periods in terms of cross-clamp period and pump times.
Conclusion: There was no sufficient data regarding the efficiency of aortic cross-clamp time and especially the
pump time in this oxidative damage. It is recommended to conduct comprehensive studies in order to obtain
sufficient, precise and reliable data regarding its effect in the oxidative damage. Additionally, the fact that CPB
triggers oxidative damage may be reduced or prevented by the studies to be conducted on antioxidant treatment in
CPB with same sensitivity. Thus, inhibition of different disease complications may allow patients undergoing
necessarily a CPB operation to maintain a more qualified life.