The Effects of Aortic Cross-Clamp and Pump Times on Oxidative Damage and Antioxidant Parameters in the Patients Undergoing Open-Heart Surgery

Creative Commons License

Doğan A., Türker F. S. , Erişir M., Ozan G., Özşensoy Y.

Chemistry Research Journal, cilt.3, sa.5, ss.73-80, 2018 (Diğer Kurumların Hakemli Dergileri)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Konu: 5
  • Basım Tarihi: 2018
  • Dergi Adı: Chemistry Research Journal
  • Sayfa Sayıları: ss.73-80


Background: The aim of the present study is to determine the correlation between the oxidative stress marker and the antioxidant parameters with the aortic cross clamp and pump times and to make contribution to the related studies. Methods: Fifty four elective patients for whom cardiopulmonary bypass operation was planned with different indications were included in this study. While sixteen of fifty four patients were female, thirty eight patients were male. MDA, GPx, GSH, CAT, and SOD were investigated in the blood samples. Results: When the change in oxidative damage and antioxidant parameters in preoperative, operative, and postoperative periods was examined in the present study; a statistically significant increase was observed in GSH level and CAT enzyme activity in operative and postoperative periods compared to preoperative period. In the present study, it was observed that there was no statistical difference in preoperative, operative, and postoperative periods in terms of cross-clamp period and pump times. Conclusion: There was no sufficient data regarding the efficiency of aortic cross-clamp time and especially the pump time in this oxidative damage. It is recommended to conduct comprehensive studies in order to obtain sufficient, precise and reliable data regarding its effect in the oxidative damage. Additionally, the fact that CPB triggers oxidative damage may be reduced or prevented by the studies to be conducted on antioxidant treatment in CPB with same sensitivity. Thus, inhibition of different disease complications may allow patients undergoing necessarily a CPB operation to maintain a more qualified life.