Abnormal regulation of the cell cycle is a feature of many neoplasms. The role of cell cycle regulators in oncogenesis has been investigated in many human tumors. Alteration of the retinoblastoma (pRb) and cyclin D1 disrupt the Rb pathway and occur in many carcinomas. However the expression of the Rh and cyclin D1 in intestinal type gastric carcinoma is unclear. The purpose of this study was to investigate the expression of Rb and cyclin D1 in resected gastric carcinoma, their adjacent nonneoplastic mucosa and normal gastric mucosa, and finally to provide insights into the role of the Rb and cyclin D1 in gastric carcinogenesis.