Effect of cervical spinal cord electrical stimulation on nitric oxide levels in brain and dermal tissues: an evaluation using by real-time nitric oxide measurement


ÖZÜM Ü. , AKYOL M. , BALABAN H. , ÖZDEMİR E. , Soydan S.

ACTA NEUROCHIRURGICA, cilt.154, ss.1641-1646, 2012 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 154 Konu: 9
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s00701-012-1331-3
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Sayfa Sayıları: ss.1641-1646

Özet

Nitric oxide synthesized from L-arginine via the nitric oxide synthase enzyme family is the main regulatory molecule in many physiological systems. The level of nitric oxide can now be measured in tissues by a direct real-time amperometric method. The effect of electrical stimulation of the upper cervical spine on the arteries that supply the brain and upper extremities has been established by experimental studies, and thus it has begun to be used in clinical practice to increase blood flow in the brain and the peripheral vascular system. The mechanism of this effect is still a subject of research. This is the first report of real-time nitric oxide measurement in living brain and dermal tissue during electrical stimulation of the upper cervical spine.