Akademik Veri Yönetim Sistemi
IX. International Congress of Molecular Medicine, 18 - 20 Aralık 2023, ss.27-28
COVID-19 is an infectious disease caused by SARS-CoV-2. Despite being very active and infectious, its symptoms vary among individuals. The researches on the genetic background are essential for elucidating the reason why COVID-19 causes mild symptoms in some people but severe symptoms in others. A number of studies have revealed that inflammation contributes to a range of complex infections. Cytokines play a role in modulating humoral and transcellular immune pathways during immune response to inflammation. The cytokine storm in COVID-19 patients is strictly regulated by the SOCS family proteins, which suppress cytokine signalling. SOCS-1, one of the eight intracellular proteins in mammalian SOCS family, is involved in the regulation of the JAK/STAT and NF-κB pathways through ubiquitin-mediated proteasomal degradation. The dysfunction of this protein affects antiviral defence in the respiratory tract. When compared to the low-risk groups for COVID-19, the high-risk groups exhibit less interferon response. This results in an excessive inflammatory response, allowing the virus to reproduce and spread even faster. A polymorphism scan of the SOCS-1 gene in asthma patients has revealed the presence of 13 different polymorphisms. The -1478CA>del polymorphism located in the promoter region was discovered to have a significant relationship with adult susceptibility, resulting higher transcription levels in the human lung epithelial cell line. Here, we therefore investigated the distribution pattern of the -1478CA>del polymorphism in COVID-19 patients with different clinical characteristics. The effect of genetic variations on clinical outcomes was assessed by associating genotypes and allele frequencies with the severity of the disease.