CCR2 Polymorphism in Chronic Renal Failure Patients Requiring Long-Term Hemodialysis

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SEZGİN İ., Koksal B., BAĞCI G., KÜÇÜK KURTULGAN H., ÖZDEMİR Ö.

INTERNAL MEDICINE, cilt.50, sa.21, ss.2457-2461, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 21
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2169/internalmedicine.50.5119
  • Dergi Adı: INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2457-2461
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective A number of chemokines and chemokine receptors are produced by intrinsic renal cells as well as by infiltrating cells during renal inflammation. The CCR2 chemokine receptor mediates leukocyte chemoattraction in the initiation and amplification phase of renal inflammation. The polymorphism, CCR2-V64I, changes valine 64 of CCR2 to isoleucine. We aimed to determine the frequency of CCR2-V64I polymorphism in patients with chronic renal failure requiring long-term hemodialysis.