Role of D-1/D-2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats

ÖZDEMİR E., BAĞÇİVAN İ., GÜRSOY S.

BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES, cilt.13, sa.2, ss.119-125, 2013 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2013
  • Dergi Adı: BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.119-125
  • Anahtar Kelimeler: dopamine receptors, perphenazine, analgesia, morphine tolerance, NUCLEUS-ACCUMBENS, ANTINOCICEPTIVE TOLERANCE, OPIOID RECEPTORS, SUBSTANTIA-NIGRA, NITRIC-OXIDE, K+-ATPASE, STRIATUM, PROTEIN, INVOLVEMENT, ACTIVATION
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood. The purpose of this study was to investigate effects of D-1/D-2 dopamine receptors antagonist perphenazine on morphine analgesia and tolerance in rats.