The Presence of PAI-1 4G/5G and ACE DD Genotypes Increases the Risk of Early-Stage AVF Thrombosis in Hemodialysis Patients

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GÜNGÖR Y., KAYATAŞ M., YILDIZ G., ÖZDEMİR Ö., CANDAN F.

RENAL FAILURE, cilt.33, sa.2, ss.169-175, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/0886022x.2011.552151
  • Dergi Adı: RENAL FAILURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.169-175
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background: In this study, we investigated the relationship between early arteriovenous fistula (AVF) thrombosis with angiotensin-converting enzyme (ACE) gene and thrombophilic factor gene polymorphisms. Methods: Thirty-five patients who suffered from three or more fistula thrombosis episodes in the early period after AVF operation and 33 control patients with no history of thrombosis for at least 3 years were enrolled in this study. Results: Factor V G1691A Leiden, factor V H1299R (R2), prothrombin G20210A, factor XIIIV34L, beta beta-fibrinogen-455 G-A, glycoprotein IIIa L33P human platelet antigens (HPA-1), methylenetetrahydrofolate reductase C677T, and methylenetetrahydrofolate reductase A1298C gene polymorphisms were similar in both groups (p > 0.05). Plasminogen activator inhibitor 1 (PAI-1) 4G//5G genotype in the study group and 4G//4G genotype in the control group were significantly higher (p == 0.014). No significant difference was detected in terms of the 5G//5G genotype. With regard to the ACE gene polymorphism, the control group showed more ID genotype (19//33, 57.6%%), whereas the study group showed more DD genotype (17//35, 48.6%%). II genotype was similar in both groups (x