Neurobiological effects of gallic acid: current perspectives

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Bhuia M. S., Rahaman M. M., Islam T., Bappi M. H., Sikder M. I., Hossain K. N., ...Daha Fazla

Chinese Medicine (United Kingdom), cilt.18, sa.1, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1186/s13020-023-00735-7
  • Dergi Adı: Chinese Medicine (United Kingdom)
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: Gallic acid, neuroprotective activity, pharmacological effects, Molecular mechanisms, Brain health
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer’s disease, Parkinson’s disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.