Determination of diazepam in human plasma by developed and validated a high-performance liquid chromatographic ultraviolet method

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DURAL E., Kaya B. N.

ISTANBUL JOURNAL OF PHARMACY, cilt.52, sa.1, ss.37-46, 2022 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.26650/istanbuljpharm.2022.877867
  • Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.37-46
  • Anahtar Kelimeler: Diazepam, Solid-phase extraction, Method validation, High-performance liquid chromatography-ultraviolet detection, THIN-LAYER-CHROMATOGRAPHY, PHARMACOKINETICS, QUANTIFICATION, METABOLITES, TOLERANCE, LORAZEPAM, MS/MS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background and Aims: Diazepam is accepted as a safer drug to medicate in many serious cases, acting as an anticonvulsant, an anxiolytic and a treatment for many types of poisoning. Monitoring it is important in achieving successful treatment and reducing the risk of toxic effects. In this study, it is aimed to develop and validate a sensitive, repeatable, and reliable method based on high-performance liquid chromatographic analysis for the determination in human plasma.