Does mammalian target of rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?

Pazarci Ö., Doğan H. O., Kilinç S., Çamurcu I.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.49, sa.6, ss.1774-1778, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.3906/sag-1809-117
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1774-1778
  • Anahtar Kelimeler: mTOR, sestrin, bone, fracture, MOLECULAR ASPECTS, MTOR, MUSCLE, PATHWAY, GROWTH, CELLS, MODEL
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Background/aim: Fracture healing is a complex physiological process that involves a well-orchestrated series of biological events. The mammalian target of rapamycin (mTOR) and sestrin 1 (SESN 1) play a central role in cell metabolism, proliferation, and survival. The aim of our study is to present serum mTOR and SESN 1 levels by comparing patients with or without bone fractures. It is also a guide for further research on the roles of these proteins in fracture healing.