Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis.

Polat Z., Walochnik J., Obwaller A., VURAL ÖZEÇ A., DURSUN A., ARICI M. K.

Clinical & experimental ophthalmology, cilt.42, sa.2, ss.151-8, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/ceo.12120
  • Dergi Adı: Clinical & experimental ophthalmology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.151-8
  • Anahtar Kelimeler: Acanthamoeba, keratitis, miltefosine, polyhexamethylene biguanide, rat keratitis model, MEDICAL-TREATMENT, CHLORHEXIDINE, DIAGNOSIS, ALKYLPHOSPHOCHOLINES, EPIDEMIOLOGY, PATHOGENESIS, CASTELLANII, RESISTANCE, EFFICACY, STRAINS
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

BackgroundIn this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis.