Miltefosine and polyhexamethylene biguanide: a new drug combination for the treatment of Acanthamoeba keratitis.
Clinical & experimental ophthalmology, cilt.42, sa.2, ss.151-8, 2014 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 2
- Basım Tarihi: 2014
- Doi Numarası: 10.1111/ceo.12120
- Dergi Adı: Clinical & experimental ophthalmology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.151-8
- Anahtar Kelimeler: Acanthamoeba, keratitis, miltefosine, polyhexamethylene biguanide, rat keratitis model, MEDICAL-TREATMENT, CHLORHEXIDINE, DIAGNOSIS, ALKYLPHOSPHOCHOLINES, EPIDEMIOLOGY, PATHOGENESIS, CASTELLANII, RESISTANCE, EFFICACY, STRAINS
- Sivas Cumhuriyet Üniversitesi Adresli: Evet
Özet
BackgroundIn this study, a series of compounds - miltefosine, polyhexamethylene biguanide, chlorhexidine and propamidine isethionate - and combinations of the latter three agents with miltefosine were prepared and used in a rat model for the topical treatment of Acanthamoeba keratitis.