SYNTHESIS AND IN VITRO ANTIMICROBIAL ACTIVITY OF NOVEL 2-(3-OXO-1,3-DIARYLPROPYLTHIO)ACETIC ACID DERIVATIVES


Gezegen H. , Karaman I., Ceylan M., Dilmac M.

ACTA POLONIAE PHARMACEUTICA, vol.69, pp.893-900, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69
  • Publication Date: 2012
  • Title of Journal : ACTA POLONIAE PHARMACEUTICA
  • Page Numbers: pp.893-900

Abstract

A series of novel 2-(3-oxo-1,3-diarylpropylthio)acetic acid derivatives (3a-l) were prepared by base catalyzed addition of thioglycolic acid to chalcones (1a-l). The antibacterial activities of synthesized compounds were screened against human pathogenic microorganisms by employing the disk-diffusion technique. For the active compounds, also minimum inhibitory concentrations (MICs) were determined.