SYNTHESIS AND IN VITRO ANTIMICROBIAL ACTIVITY OF NOVEL 2-(3-OXO-1,3-DIARYLPROPYLTHIO)ACETIC ACID DERIVATIVES
ACTA POLONIAE PHARMACEUTICA, cilt.69, ss.893-900, 2012 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 69
- Basım Tarihi: 2012
- Dergi Adı: ACTA POLONIAE PHARMACEUTICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.893-900
- Sivas Cumhuriyet Üniversitesi Adresli: Hayır
Özet
A series of novel 2-(3-oxo-1,3-diarylpropylthio)acetic acid derivatives (3a-l) were prepared by base catalyzed addition of thioglycolic acid to chalcones (1a-l). The antibacterial activities of synthesized compounds were screened against human pathogenic microorganisms by employing the disk-diffusion technique. For the active compounds, also minimum inhibitory concentrations (MICs) were determined.