An air-assisted dispersive liquid phase microextraction method based on a hydrophobic magnetic deep eutectic solvent for the extraction and preconcentration of melamine from milk and milk-based products

ELİK A., FESLİYAN S., GÜRSOY N., Haq H. U., Castro-Muñoz R., ALTUNAY N.

Food Chemistry, cilt.426, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 426
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.foodchem.2023.136573
  • Dergi Adı: Food Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Dispersive liquid phase microextraction, Hydrophobic magnetic deep eutectic solvent, Melamine, Milk-based products, Multivariate optimization
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

In the current research, a fast and sustainable air-assisted hydrophobic magnetic deep eutectic solvent-based dispersive liquid phase microextraction followed by UV–Vis spectrophotometry measurements was optimized for the extraction and determination of melamine in milk and milk-based products. The central composite design was applied for the optimization of factors affecting the recovery of melamine. Quantitative extraction of melamine was achieved using hydrophobic magnetic deep eutectic solvents prepared from a mixture of octanoic acid, aliquat-336, and cobalt(II) chloride. The optimum conditions for extraction were found as follows: 6 extraction cycles, pH 8.2, extraction solvent volume 260 µL, and acetone volume 125 µL. Interestingly, a centrifugation step was not required to achieve phase separation. Under the optimum conditions, melamine was determined in the linear range of 3–600 ng mL−1, the limit of detection (3Sblank/m) of 0.9 ng mL−1, and the enrichment factor of 144. The validation of the method was investigated by the analysis of reference materials. Consequently, the method was successfully applied for the analysis of melamine residues in milk and milk-based products.