Karl R. Popper is an important philosopher of science of 20th Century and is known in this field through his theory of falsification. But the critical theory of rationality is indeed his basic theory and it can be seen in his whole idea. Critique of historicism also contains his views on the social and political philosophy in a systematic context in relation to them. Popper embodied his views about the historicism through human-centered thoughts of philosophers such as Plato, Aristotle, Marx and Hegel who are effective system builders and he raised a number of criticism against the holistic structures. We discuss in this article Popper's critique of historicism, especially his critics related with Plato, Aristotle, Hegel and Marx.