SYNTHESIS AND SCREENING ANTIMICROBIAL ACTIVITIES OF NOVEL 1,3-DIARYL-3-(PHENYLTHIO)PROPAN-1-ONE DERIVATIVES


Karaman I., Gezegen H. , Ceylan M., Dilmac M.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.187, pp.580-586, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 187
  • Publication Date: 2012
  • Doi Number: 10.1080/10426507.2011.632387
  • Title of Journal : PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Page Numbers: pp.580-586

Abstract

In this study, a series of novel beta-mercapto carbonyl derivatives (3a-j) was prepared by addition of thiophenol (2) to chalcones (1a-j) in the presence of catalytic amount of iodine (10 mol%) in CH2Cl2. Antibacterial and antifungal in vitro properties of the synthesized compounds were tested against some human pathogenic microorganisms by employing the disk diffusion technique. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.