SYNTHESIS AND SCREENING ANTIMICROBIAL ACTIVITIES OF NOVEL 1,3-DIARYL-3-(PHENYLTHIO)PROPAN-1-ONE DERIVATIVES


Karaman I., Gezegen H. , Ceylan M., Dilmac M.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.187, ss.580-586, 2012 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 187
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1080/10426507.2011.632387
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Sayfa Sayıları: ss.580-586

Özet

In this study, a series of novel beta-mercapto carbonyl derivatives (3a-j) was prepared by addition of thiophenol (2) to chalcones (1a-j) in the presence of catalytic amount of iodine (10 mol%) in CH2Cl2. Antibacterial and antifungal in vitro properties of the synthesized compounds were tested against some human pathogenic microorganisms by employing the disk diffusion technique. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.