SYNTHESIS AND SCREENING ANTIMICROBIAL ACTIVITIES OF NOVEL 1,3-DIARYL-3-(PHENYLTHIO)PROPAN-1-ONE DERIVATIVES

Karaman I., Gezegen H., Ceylan M., Dilmac M.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.187, ss.580-586, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 187
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1080/10426507.2011.632387
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.580-586
  • Anahtar Kelimeler: Chalcone, thiophenol, Michael addition, antibacterial and antifungal activity, CATALYZED MICHAEL ADDITION, ALPHA,BETA-UNSATURATED KETONES, ANTIHYPERGLYCEMIC ACTIVITY, BIOLOGICAL-ACTIVITY, CONJUGATE ADDITION, MERCAPTANS
  • Sivas Cumhuriyet Üniversitesi Adresli: Hayır

Özet

In this study, a series of novel beta-mercapto carbonyl derivatives (3a-j) was prepared by addition of thiophenol (2) to chalcones (1a-j) in the presence of catalytic amount of iodine (10 mol%) in CH2Cl2. Antibacterial and antifungal in vitro properties of the synthesized compounds were tested against some human pathogenic microorganisms by employing the disk diffusion technique. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.