Effects of experimental obstructive jaundice on contractile responses of dog isolated blood vessels: Role of endothelium and duration of bile duct ligation


Creative Commons License

Utkan Z., Utkan T., Sarioglu Y., Gonullu N.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.27, pp.339-344, 2000 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27
  • Publication Date: 2000
  • Doi Number: 10.1046/j.1440-1681.2000.03256.x
  • Title of Journal : CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Page Numbers: pp.339-344

Abstract

1. We examined the effects of experimental obstructive jaundice caused by bile duct ligation (BDL) on vascular smooth muscle function, as well as the underlying mechanisms involved, by recording responses to noradrenaline (NA), 5-hydroxy-tryptaminc (5-HT) and acetylcholine (ACh) in canine isolated renal arteries and to NA in Isolated mesenteric arteries in vitro. All studies were performed 7 days after the onset of BDL in renal arteries and 3, 7 and 15 days after the onset of BDL in mesenteric arteries.