Akademik Veri Yönetim Sistemi
Monatshefte fur Chemie, 2026 (SCI-Expanded, Scopus)
Four novel bioactive boron containing compounds (BCCs) were prepared by the reactions of quercetin and various boronic acids using a Dean-Stark technique to remove the H2O formed as a result of the chemical reaction. The antiepileptic properties of the bioactive BCCs also were investigated under suitable conditions. For this aim, the effect of the BCCs on the enzyme activities of carbonic anhydrase I and II isoenzymes (hCA I and hCA II) were evaluated spectrophotometrically. The bioactive BCCs have been investigated for their potential anticancer properties against PC-3, Du-145, and HEK-293 T cell lines utilizing the WST-1 assay method. Notably, the IC50 values of both boron compounds against the healthy control HEK-293 T cells were significantly higher compared to those observed in cancer cells. Lastly, bioactive boron containing compounds were examined through Gaussian calculations employing the B3LYP, HF, and M062X methods on the 6–31 + + g(d,p) basis set. Computational molecular docking was performed on specific proteins and ADME/T calculations were conducted to analyze the effects and interactions of these compounds at human metabolism.