Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study

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Guvey H., Caliskan C. S., Celik S., YURTCU N., Hatirnaz S., AVCI B., ...Daha Fazla

TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY, cilt.19, sa.2, ss.104-110, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4274/tjod.galenos.2022.25307
  • Dergi Adı: TURKISH JOURNAL OF OBSTETRICS AND GYNECOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.104-110
  • Anahtar Kelimeler: Cadherin 6, cadherin 11, preeclampsia, severe preeclampsia, early-onset preeclampsia, EPITHELIAL-MESENCHYMAL TRANSITION, REGULATED EXPRESSION, CELLS, CYTOTROPHOBLASTS, DIFFERENTIATION, AGGREGATION, FUSION, ROLES
  • Sivas Cumhuriyet Üniversitesi Adresli: Evet

Özet

Objective: Preeclampsia is a highly morbid disease of placental origin, life-threatening condition for both a pregnant woman and her fetus. Cadherin 6 and 11 are adhesion molecules that play an important role in trophoblastic development and placentation. In our study, we investigated the change in serum cadherin 6 and 11 levels in pregnant women with preeclampsia. Materials and Methods: Pregnant women with preeclampsia were selected and compared with healthy women (as a control group) for a one-year study. The serum alanine aminotransferase, aspartate aminotransferase, and cadherin levels 6 and 11 of participants were analyzed and compared. Results: A total of 189 pregnant women were subdivided into 2 groups as preeclamptic (n=94) and women with healthy pregnancy (n=95). The cadherin 6 and cadherin 11 levels of the preeclamptic patients were significantly higher than those in the control group (p=0.001), and they were found to be significantly higher mainly in patients with early-onset and severe preeclampsia group (p=0.001). The cut-off cadherin 6 and 11 values for severe preeclampsia were found as 98.174 ng/mL and 1.92 ng/mL; with sensitivity of 88.3% and 84% respectively (p=0.001). Conclusion: The data analysis showed elevated serum cadherin 6 and 11 levels associated with the severity and early onset of pre-eclampsia. Serum cadherin 6 and 11 levels can be a candidate marker for the prediction of preeclampsia.