Kolorektal ve meme kanserli hastalarda serum leptin düzeylerinin belirlenmesi

Tezin Türü: Yüksek Lisans

Tezin Yürütüldüğü Kurum: Sivas Cumhuriyet Üniversitesi, Fen Bilimleri Enstitüsü, BİYOLOJİ, Türkiye

Tezin Onay Tarihi: 2013

Tezin Dili: Türkçe


Danışman: Şeker Dağ


World Health Organization defines obesity as a decreasing health conditions, as a consequences of high lipid accumulation in adipose tissue. Nowadays, researchers showed that obesity is related to various cancer types as well as many other diseases. Cancer is the most important health problem in these days.

Obesity effect on body hormonal level and as a result of metabolic changes cause in increasing cancer risk. There are many factors cause obesity. There is a correlation between obesity and leptin which is secreted from adipose tissue as an adipocin. Clinical and in-vitro studies showed that there is a correlation between leptin and mammary cancer, colon cancer, prostate cancer and lung cancer as well.

Deficiency of leptin result obesity is well known these days. Secretion of leptin mainly by the adipose tissue effects on hypothalamus specific receptors that regulates energy intake and utilization of energy balance which functions as an antiobesity factors. In defining sera leptin level body mass index (BMI), amount of body fat and gender are most important parameters.

The data on the relationship between leptin levels and cancer are controversial. Leptin levels are reported as high in breast cancer patients but on the contrary low in the patient with gastrointestinal cancer. In the present study, blood samples were collected from who diagnosed with colorectal (n = 36, age range =18-75), breast cancer(n = 36, age range =18-75) and healthy individuals (n = 71, age range =18-75),. For these groups, leptin levels were determined and analyzed statically. After these analyses, relationship between leptin levels with Body Mass Index (BMI), body fat, Body Surface Area (BSA), and other various parameters such as gender for colorectal, breast cancer patients and healthy individuals were evaluated.

Significant changes were observed in cancer patients compared to healthy individuals for analyzed parameters. In this study, it was determined that serum leptin level was much higher in cancer patient than healthy individuals