Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Sivas Cumhuriyet Üniversitesi, Fen Bilimleri Enstitüsü, BİYOLOJİ, Türkiye
Tezin Onay Tarihi: 2013
Tezin Dili: Türkçe
Öğrenci: YAVUZ YILDIR
Danışman: Şeker Dağ
Özet:
World Health Organization defines obesity as a
decreasing health conditions, as a consequences of high lipid accumulation in
adipose tissue. Nowadays, researchers showed that obesity is related to various
cancer types as well as many other diseases. Cancer is the most important
health problem in these days.
Obesity effect on body
hormonal level and as a result of metabolic changes cause in increasing cancer
risk. There are many factors cause obesity. There is a correlation between
obesity and leptin which is secreted from adipose tissue as an adipocin.
Clinical and in-vitro studies showed
that there is a correlation between leptin and mammary cancer, colon cancer,
prostate cancer and lung cancer as well.
Deficiency of leptin result
obesity is well known these days. Secretion of leptin mainly by the adipose
tissue effects on hypothalamus specific receptors that regulates energy intake
and utilization of energy balance which functions as an antiobesity factors. In
defining sera leptin level body mass index (BMI), amount of body fat and gender
are most important parameters.
The data on the relationship between leptin levels and cancer are controversial. Leptin levels are reported as high in breast cancer patients but on the contrary low in the patient with
gastrointestinal cancer. In the present study, blood samples were collected
from who diagnosed with colorectal (n = 36, age range
=18-75), breast cancer(n = 36, age range =18-75) and healthy individuals (n =
71, age range =18-75),. For these groups, leptin levels were determined and
analyzed statically. After these analyses, relationship between leptin levels
with Body Mass Index (BMI), body fat, Body Surface Area (BSA), and other
various parameters such as gender for colorectal, breast cancer patients and
healthy individuals were evaluated.
Significant changes were observed in cancer patients compared to healthy individuals for analyzed
parameters. In this study, it was determined that serum
leptin level was much higher in cancer patient than healthy individuals