Evaluation of genotoxic effects of five flavour enhancers (glutamates) on the root meristem cells of Allium cepa


Turkoglu S.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.31, ss.792-801, 2015 (SCI İndekslerine Giren Dergi) identifier

  • Cilt numarası: 31 Konu: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/0748233713475509
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Sayfa Sayıları: ss.792-801

Özet

The effects of different treatments with flavour enhancers monosodium glutamate, monopotassium glutamate, calcium diglutamate, monoammonium glutamate, and magnesium diglutamate on the cytology, DNA content, and interphase nuclear volume (INV) of A. cepa were investigated. Three concentrations of these additives - 20, 40, and 60ppm - were applied for 6, 12, and 24h. All the concentrations of these chemicals showed an inhibitory effect on cell division in root tips of A. cepa and caused a decrease in mitotic index values. Additionally, all the treatments changed the frequency of mitotic phases when compared with the control groups. These compounds increased chromosome abnormalities, among them are micronuclei, c-mitosis, anaphase bridges, stickiness, binucleus, laggards, and breaks. The nuclear DNA content and INV decreased when compared with control groups.